In this paper a novel PCB modelling and solving method has been developed to address the so-called resource constrained project scheduling problem (RCPSP) where project tasks have multiple modes and also the preemption of activities are allowed.To solve this NP-hard problem, a new general optimization via simulation (OvS) approach has been develope
The chirality quantification is of great importance in structural biology, where the differences in proteins twisting can provide essentially different physiological effects.However, this aspect of the chirality is still poorly studied for helix-like supramolecular structures.In this work, a method PCB for chirality quantification based on the calc
Anaplastic lymphoma kinase (ALK) is validated as a therapeutic molecular target in multiple malignancies, such as non-small cell lung cancer (NSCLC).However, the feasibility of targeted therapies exerted by ALK inhibitors is inevitably hindered owing to drug resistance.The emergence of clinically acquired drug mutations has become a major challenge
Neon Indicator Lens Quantitative Trait Loci (QTL) analyses in immortal populations are a powerful method for exploring the genetic mechanisms that control interactions of organisms with their environment.However, QTL analyses frequently do not culminate in the identification of a causal gene due to the large chromosomal regions often underlying QTL